运动康复对心血管疾病内皮祖细胞的动员作用及机制

The Mobilization Effects and Mechanism of Exercise Training on Endothelial Progenitor Cells in Cardiovascular Disease

内皮祖细胞是一种新型生物标志物,其数量下降可预测心血管不良事件的高发生率。目前运动康复降低心血管疾病死亡率及提高患者生活质量已成为研究热点。大量研究证明运动康复可促进内皮祖细胞动员及改善内皮功能,但其具体机制尚不十分明确。目前认为其可能与缺血刺激和重要体液因子的调节密切相关。文章将运动康复对心血管疾病内皮祖细胞的动员作用及机制作一综述。

As a new kind of biomarker,the decreased numbers of endothelial progenitor cells can predict the high incidence of cardiovascular events. Nowadays exercise rehabilitation has become a research hotspot,since it can reduce the morbidity of cardiovascular disease and improve the patients’ quality of life. Multiple evidence has demonstrated that cardiovascular rehabilitation can mobilize the endothelial progenitor cells and improve endothelia function,but the mechanism of mobilization is not fully understood,which seems to be closely related to the ischemic stimulation and the regulation of important humoral factors. This review will summarize the effects of exercise training on mobilization of endothelial progenitor cells in patients with cardiovascular disease and discuss the possible mechanisms involved.