早发男性非糖尿病冠心病患者健康相关生活质量及危险因素分析

Analysis Between Health-related Quality Life and Risk Factors in Non-diabetic Premature Coronary Heart Disease Man

目的分析早发男性非糖尿病冠心病患者健康相关生活质量及危险因素相关性。方法搜集2012年1月至2015年1月在中山大学孙逸仙纪念医院心内科住院男性、年龄≤50岁、非糖尿病患者215例,均行冠状动脉造影检查,其中冠状动脉狭窄≥50%诊断为冠心病的患者104例为早发男性非糖尿病冠心病组;冠状动脉狭窄<50%111例为男性非糖尿病对照组,搜集临床资料及健康相关生活质量调查。结果早发男性非糖尿病冠心病组中,高血压、高脂血症、吸烟、家族史、收缩压、舒张压水平显著高于男性非糖尿病对照组(均P<0.05);早发男性非糖尿病冠心病组中,教育水平低、压力大、过度劳累比例显著高于男性非糖尿病对照组(均P<0.05);校正吸烟、饮酒、高血压、高脂血症、高尿酸血症、冠心病家族史、教育水平低、压力大、过度劳累等危险因素后,吸烟(OR=5.005,95%CI:2.096~11.954)、高血压(OR=3.704,95%CI:1.466~9.355)、压力大(OR=2.635,95%CI:1.309~5.302)、过度劳累(OR=2.594,95%CI:1.192~5.648)均显著增加早发非糖尿病男性冠心病发病风险(均P<0.05)。结论早发非糖尿病男性中吸烟、高血压、压力大、过度劳累均为冠心病发病风险,其中吸烟风险最大。

Aim To investigate the correlation between health-related quality life( HRQL) and risk factors in non-diabetic premature coronary heart disease( CHD) man. Methods 215 non-diabetic man patients( age fewer than50) were selected from cardiology department( Sun Yat-sen Memorial Hospital of Sun Yat-sen University) from January2012 to January 2015. All subjects were diagnosed by coronary angiography and divided into two groups according to the percentage of coronary artery stenosis as follows: 104 cases with coronary artery stenosis above 50%( age 43. 04 ± 4. 69,CHD group) and 111 cases with coronary artery stenosis less than 50%( age 42. 92 ± 4. 30,Healthy control group).Clinical data and health-related quality information were collected and analyzed by SPSS 18. 0. Results 1) Hypertension,hyperlipidemia,smoking,family history,diastolic blood pressure and systolic blood pressure were significantly higher in the CHD group than that of the healthy control group( P < 0. 05); 2) The proportion of low education,stress pressure and excess fatigue were significantly higher in the CHD group than that of the healthy control group( P < 0. 05); 3) Smoking,hypertension,high pressure and excess fatigue significantly increased the incidence of coronary heart disease in nondiabetic man patients after adjusting the relative risk factors,which included smoking,drinking,hypertension,hyperlipidemia,hyperuricemia,the family history of coronary heart disease,low education,stress pressure and excess fatigue.The odds ratio( OR) and 95% CI for smoking,hypertension,stress pressure and excess fatigue were 5. 005( 2. 096,11. 954),3. 704( 1. 466,9. 355),2. 635( 1. 309,5. 302),2. 594( 1. 192,5. 648) respectively( P < 0. 05).Conclusion Our data suggest that smoking,hypertension,stress pressure and excess fatigue are the risk factors of premature CHD in non-diabetic man,and smoking is the most significant risk factor in this study.