炎症消散的缺失诱发As斑块形成的作用机制及中药复方干预As炎症新思路的探索

Mechanism of Defective Inflammation Resolution in Atherosclerosis and New Exploration of Traditional Chinese Medicine Intervention in Atherosclerosis Inflammation

动脉粥样硬化(As)是心脑血管疾病发病和死亡的主要病理基础之一。抗炎是防治As的一条有效途径,一些新型的抗炎药物已经进入了临床研究阶段。近年来的研究发现,炎症消散的缺失也是As斑块形成和破裂的重要因素。本文基于抗炎治疗在As防治中的研究进展,从炎症消散的角度出发,系统总结了炎症消散各方面的缺失对As斑块形成的影响。并深入探讨了胞葬作用在As早期和As斑块成熟期的变化及其所呈现出不同结果的原因。此外,本文结合As炎症消散缺失的作用机制,思考并探讨中医药干预As炎症消散可能的作用靶点,为寻求针对抗炎和促炎症消散双方面调节的抗As药物提供科学依据和理论参考。

Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. Anti-inflammatory therapies hold great promise in cardiovascular prevention and several novel anti-inflammatory drugs have reached clinical development stage. In recent years,the study found that defective inflammation resolution is also important in deciphering the complex process of atherosclerosis progression. Here,this article summarizes the critical aspects of defective inflammation resolution and its influence on Atherosclerosis plaque formation,deeply discusses the efferocytosis of apoptotic macrophages and how it may go awry in advanced atheroma. In addition,this article combines with the mechanism of defective inflammation resolution,discusses the intervention of Traditional Chinese Medicine in inflammation resolution potential targets,in order to seek both anti-inflammatory and pro-inflammatory resolution atherosclerosis drugs and provide scientific and theoretical basis.