炎性信号通路在动脉粥样硬化中的机制与中医药干预作用研究进展

Research Progress on Mechanism of Inflammatory Signaling Pathway in Atherosclerosis and the Intervention of Traditional Chinese Medicine

动脉粥样硬化(As)是冠心病、脑卒中等疾病的重要病理基础,除脂质代谢紊乱、血管内皮损伤、氧化应激反应等危险因素外,炎性信号通路介导的炎症反应作为新的危险因素贯穿于As的形成发展过程中已得到广大研究者的认可。中医药因其作用广,毒副作用小,被广泛应用于防治As中。本文就炎性信号通路在As中的作用机制,以及中医药通过干预炎性信号通路在抗As机制方面的研究进展作一综述。

Atherosclerosis( As) is an important pathological basis of coronary heart disease,cerebral apoplexy disease. In addition to the disorder of lipid metabolism,vascular endothelial injury,oxidative stress and risk factors,many researchers have approved that inflammatory signaling pathway as new risk factors mediated through the formation process of As. Traditional Chinese medicine because of its wide effect,small toxic and side effect,is widely used in the prevention and treatment of As. In this paper,we summarized the action mechanism of inflammatory signaling pathways in As and progress of anti As mechanism of traditional Chinese medicine through intervention in inflammatory signal pathway.