我国动脉粥样硬化基础研究近三年进展

The Progress of the National Preclinical Research of Atherosclerosis in the Recent Three Years

动脉粥样硬化一直是我国医学研究领域的热点和重点。近三年来我国学者对动脉粥样硬化发生发展进行了大量工作,主要集中在动脉粥样硬化模型制备;自噬和凋亡、氧化应激、血管平滑肌增殖、炎症、脂蛋白、非编码RNA等方面与动脉粥样硬化的关系;动脉粥样硬化发生的基因多态性及流行病学研究等。可以看出细胞自噬与凋亡、表观遗传学机制、信号通路、microRNA、LncRNA、PCSK9以及模拟肽的应用已成为当前动脉粥样硬化研究领域的新热点和趋势,这为预防和治疗动脉粥样硬化疾病提供一定新的理论依据,但与国际研究的前沿相比尚有一定差距。

The research on the development of atherosclerosis has been recognized as the hot and key point in medical research of China. Focusing on the model and the pathogenesis of atherosclerosis,Chinese researchers executed mass studies in the recent three years,like apoptosis and autophagy,oxidative stress,vascular smooth muscle cell proliferation,vascular inflammation,the function of lipoprotein,non-coding RNA; gene polymorphism and epidemiological studies of atherosclerosis,and other aspects that could induce atherosclerosis. What's more,the investigations on apoptosis and autophagy,epigenetic mechanisms,signal pathway,microRNA,LncRNA,PCSK9 and the application of apolipoprotein mimetic peptide have been the tendency in the cure of atherosclerosis. Chinese researchers have provided several new theories on preventing and curing atherosclerosis,however,a certain gap is still existed between Chinese and international researches.