氧化型高密度脂蛋白与动脉粥样硬化被引量：3

Research Progress of Oxidized High Density Lipoprotein and Atherosclerosis

下载PDF

导出

摘要高密度脂蛋白(HDL)在体内经过髓过氧化物酶氧化形成不同位点修饰的HDL(ox-HDL),ox-HDL通过损伤内皮细胞、影响胆固醇逆转运过程、促进平滑肌增生等方式降低抗动脉粥样硬化的作用。因此HDL不同位点的氧化修饰及相关功能改变或将为治疗动脉粥样硬化提供新的思路。 High density lipoprotein can be modified in various amid acid sites through myeloperoxidase( MPO).ox-HDL can damage endothelia cells,lose the ability of reverse cholesterol transport,promote smooth muscle cell proliferation which will decrease HDL anti-atherosclerosis capacity. Therefore the association between HDL specific sites modification and function changes will provide a new method to prevent atherosclerosis.

作者董敏赵明明潘兵郑乐民

机构地区北京大学心血管研究所

出处《中国动脉硬化杂志》 CAS 北大核心 2015年第12期1215-1218,共4页 Chinese Journal of Arteriosclerosis

基金国家自然科学基金面上项目(81370235 81170101)

关键词高密度脂蛋白氧化修饰动脉粥样硬化 High Density Lipoprotein Oxidation Atherosclerosis

分类号 R543.5 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献26

1Michael C Phillips,Kristin L Gillotte,M.Page Haynes,William J Johnson,Sissel Lund-Katz,George H Rothblat.??Mechanisms of high density lipoprotein-mediated efflux of cholesterol from cell plasma membranes(J)Atherosclerosis . 1998
2Huang Y,DiDonato JA,Levison BS,et al.An abundant dysfunctional apolipoprotein Al in human atheroma. Nature Medicine . 2014
3Di Donato JA,Aulak K,Huang Y,et al.Site-specific nitration of apolipoprotein A-Ⅰat tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. Journal of Biological Chemistry . 2014
4Undurti Arundhati,Huang Ying,Lupica Joseph A,Smith Jonathan D,DiDonato Joseph A,Hazen Stanley L.Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. Journal of Biological Chemistry . 2009
5Thomas F. Lüscher,Ulf Landmesser,Arnold von Eckardstein,Alan M. Fogelman.??High-Density Lipoprotein: Vascular Protective Effects, Dysfunction, and Potential as Therapeutic Target(J)Circulation Research . 2014 (1)
6Jonathan E. Feig,Bernd Hewing,Jonathan D. Smith,Stanley L. Hazen,Edward A. Fisher.High-Density Lipoprotein and Atherosclerosis Regression: Evidence From Preclinical and Clinical Studies[J]. Circulation Research . 2014 (1)
7Bing Pan,Baoqi Yu,Hui Ren,Belinda Willard,Ling Pan,Lingyun Zu,Xiaoli Shen,Yijing Ma,Xiuli Li,Chenguang Niu,Jinge Kong,Siyu Kang,Y. Eugene Chen,Subramaniam Pennathur,Lemin Zheng.??High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair(J)Free Radical Biology and Medicine . 2013
8Alice Assinger,Franz Koller,Werner Schmid,Maria Zellner,Rita Babeluk,Elisabeth Koller,Ivo Volf.??Specific binding of hypochlorite-oxidized HDL to platelet CD36 triggers proinflammatory and procoagulant effects(J)Atherosclerosis . 2010 (1)
9Jingyi Ren,Wenying Jin,Hong Chen.??oxHDL decreases the expression of CD36 on human macrophages through PPARγ and p38 MAP kinase dependent mechanisms(J)Molecular and Cellular Biochemistry . 2010 (1)
10Dao-Quan Peng,Gregory Brubaker,Zhiping Wu,Lemin Zheng,Belinda Willard,Michael Kinter,Stanley L. Hazen,Jonathan D. Smith.??Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function(J)Arteriosclerosis, Thrombosis, and Vascular Biology . 2008 (11)