对氧磷酶1在高密度脂蛋白结构与功能中的意义

Role of Paraoxonase 1: Implication in the Structure and Function of High Density Lipoprotein

高密度脂蛋白(HDL)的抗氧化抗炎活性很大程度归因于对氧磷酶1(PON1)的存在。PON1主要由肝脏合成入血,经极低密度脂蛋白运输结合于HDL上,并在不同HDL亚型间转移,可与HDL组成蛋白相互作用而发挥高活性,对于维持HDL基本结构及抗氧化抗炎功能具有重要作用。PON1的量及活性变化与HDL结构异常密切相关,并在一定程度上反映HDL抗动脉粥样硬化功能的改变。本文就PON1与HDL的结合、相互作用及与HDL功能的相关性作一综述。

The anti-oxidative and anti-inflammatory activities of high density lipoproteins( HDL) are largely due to the paraoxonase 1( PON1) located on it. PON1 is mainly synthesized in the liver and secreted into the circulation,using very low density lipoprotein( VLDL) as a vehicle to bind with HDL,and transferred between in the HDL subclasses.PON1 possesses a higher activity through interacting with other protein components in HDL,and plays an important role for HDL structure and its anti-oxidative and anti-inflammatory activities. The change in quantity and activity of PON1 is associated with abnormal structure and the atherogenic 'dysfunction'of HDL. In this review we summarize data on the role played by PON1 on HDL structure and function,focusing on the relationship between their binding and interaction and function of HDL.