动脉粥样硬化进程中单核/巨噬细胞的行为变化

Behavior Changes of Monocytes and Macrophages in the Process of Atherosclerosis

动脉粥样硬化是由脂质引发的炎症性疾病,单核/巨噬细胞在动脉粥样硬化发生发展过程中发挥极其重要的作用。巨噬细胞吞噬脂质后成为泡沫细胞,构成动脉粥样硬化的脂质条纹和粥样斑块。过去几年中,对于单核细胞如何聚集、分化、摄取脂质及其在动脉粥样硬化中的作用有了进一步了解。单核/巨噬细胞表型和功能的复杂性提示其很可能会成为动脉粥样硬化治疗的靶点。本文就单核/巨噬细胞在动脉粥样硬化进程中的行为变化进行综述。

Atherosclerosis is an inflammatory disease caused by lipid. Monocytes and their descendant macrophages play an important role in the occurrence and development of atherosclerosis. Macrophages become foam cells after lipid-laden,and foam cells form the lipid stripes and plaques of atherosclerosis. Over the past several years,the understanding of how monocytes accumulate in the growing lesion,differentiate,ingest lipids,and their roles in atherosclerosis has advanced substantially. Monocyte / macrophage's phenotype and functional complexity suggests that it is likely to become a new target for the treatment of atherosclerosis. Monocyte / macrophage's behavior changes in the process of atherosclerosis are reviewed in this article.