阿托伐他汀联合快步运动对颈动脉斑块逆转的影响

Effect of atorvastatin combined with brisk walking on carotid plaque reversal

目的研究阿托伐他汀联合快步运动对动脉粥样斑块逆转的效果。方法将120例动脉粥样硬化患者分为他汀组和联合组。他汀组给予阿托伐他汀钙片20 mg/d(北京阿乐)口服,联合组在阿托伐他汀钙片20mg/d口服基础上联合快步运动(4～5天/周),随访2年。采用颈部血管超声评估颈部血管动脉硬化斑块面积、颈动脉内膜中膜厚度(IMT)、稳定斑块率来评估斑块逆转效果。结果联合组在降低甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)水平,提高高密度脂蛋白胆固醇(HDLC)方面优于他汀组。联合组对颈动脉斑块IMT、最大斑块面积、斑块数量及提高稳定斑块率方面优于他汀组。结论他汀类药物联合快步有氧运动能够降低LDLC、TC、TG水平,提高HDLC的水平及功能,增加斑块稳定性,具有逆转斑块的作用,且随着时间延长,抗动脉硬化作用增强。

Aim To study the effect of atorvastatin combined with brisk walking on atherosclerotic plaques reversal. Methods 120 atherosclerotic patients were divided into statin group and combined group. Carotid atherosclerotic plaque area,carotid intima-media thickness and stable plaque rate were used to evaluate plaque reversal effect. Statin group was given atorvastatin calcium tablets 20 mg/d( Beijing Ale) orally. The combined group took a quick walk( 4 ～ 5 days/week) on the basis of atorvastatin calcium tablets 20 mg/d. The follow-up was 2 years. Results The combined group was superior to statin group in reducing TG,TC,LDLC and increasing HDLC. The combined group was superior to statin group in carotid artery plaque IMT,maximum plaque area,plaque number and stable plaque rate. Conclusion The combination of statins and fast aerobic exercise can improve the anti-atherosclerotic effect and reduce the level and function of LDLC,TC and TG,increase the level and function of HDLC,increase the stability of plaque,reverse the plaque effect,and increase the anti-arteriosclerosis as the time prolongs.