颅内动脉狭窄的遗传学研究进展

Advances in genetic study of intracranial arterial stenosis

随着CT血管成像(CTA)、磁共振血管成像(MRA)、数字减影血管造影技术(DSA)等检查普及,颅内动脉狭窄的检出率提高,从无症状到头昏等轻微症状,再到卒中发作,均可作为颅内动脉狭窄的临床表现。作为一个多病因疾病,其发病机制复杂,且缺血性卒中复发率高,逐渐受到研究者的关注。颅内动脉狭窄的患者存在年龄分布、性别及种族等差异,提示遗传因素在其中有着重要作用。目前关于颅内动脉狭窄遗传因素方面的研究取得一些进展。

With the popularization of CT angiography,magnetic resonance angiography and digital subtraction angiography( DSA),the detection rate of intracranial artery stenosis is improved. Intracranial artery stenosis causes a diversity of clinical manifestation. For example,asymptomatic,dizziness and stroke and so on. As a multi-etiological disease,its pathogenesis is complex,and the recurrence rate of ischemic stroke is high. Intracranial artery stenosis have different distribution in age,sex and race. This may suggest that genetic factors play an important role. At present,some progress has been made in genetic factors of intracranial artery stenosis.