摘要
肝X受体(LXR)是机体胆固醇稳态维持的重要调控因子,通过调控下游靶基因表达,参与调节各组织中的胆固醇代谢。LXR激动剂能够促进胆固醇逆向转运,发挥抗动脉粥样硬化作用,具有潜在治疗心血管疾病的作用。本文围绕近年来新型LXR激动剂,从不同来源、特点和作用机制等角度对其发挥抗动脉粥样硬化作用进行综述。
Liver X receptors(LXRs) are nuclear factors and play important roles in the regulation of cholesterol homeostasis in the body.LXRs regulate cholesterol metabolism in different tissues through regulating their target genes.LXR agonists can promote the reverse cholesterol transport in order to inhibit atherosclerosis,and have potential therapeutic effects on cardiovascular diseases.In this paper,the new LXR agonists in recent years are reviewed for their anti-atherosclerotic effects from different sources,characteristics and mechanisms.
作者
付育
李霓
FU Yu;LI Ni(College of Bioscience and Bioengineering,Hebei University of Science and Technology,Shijiazhuang,Hebei 050018,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,ChineseAcademy of Medical Sciences,Peking Union Medical College,Beijing 100050,China;National Center for MicrobialDrug Screening,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050,China)
出处
《中国动脉硬化杂志》
CAS
2019年第3期254-263,共10页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81503065
81402305)
河北省自然科学基金项目(H2015208141)
河北省高等学校科学技术研究项目(BJ2016024)
关键词
肝X受体
激动剂
动脉粥样硬化
胆固醇代谢
liver X receptors
agonist
atherosclerosis
cholesterol metabolism
