新疆沙湾县哈萨克族血浆低叶酸水平与其原发性高血压高患病率相关

Low plasma folic acid level is associated with high prevalence of essential hypertension in Kazak in Shawan County of Xinjiang

目的研究新疆沙湾县哈萨克族血浆叶酸水平与原发性高血压(EH)之间的关系。方法以新疆沙湾县哈萨克族641例和汉族702例为研究对象,其中EH组654例,正常血压的对照组689例。收集所有研究对象性别、年龄、体质指数、腰臀比、生物化学指标等一般资料。采集血样,用ACCESS全自动微粒子化学发光免疫分析系统检测血浆叶酸水平。结果 (1)哈萨克族血浆叶酸水平低于汉族(P<0. 01),EH组血浆叶酸水平低于对照组(P<0. 01),男性血浆叶酸水平低于女性(P<0. 01)。(2)按性别分层后,男性哈萨克族EH组血浆叶酸水平明显低于对照组(P<0. 05),女性汉族EH组血浆叶酸水平明显低于对照组(P<0. 01);哈萨克族人群中,男性血浆叶酸水平明显低于女性(P<0. 05);无论男性女性,哈萨克族血浆叶酸水平明显低于汉族(P<0. 01)。(3) EH组、对照组血浆叶酸水平哈萨克族均明显低于汉族(P<0. 01);在EH组和对照组内,无论男性还是女性,哈萨克族血浆叶酸水平均明显低于汉族(P<0. 05)。结论新疆沙湾县哈萨克族血浆叶酸水平低于汉族,EH患者血浆叶酸水平低于正常人。哈萨克族血浆低叶酸水平与EH高患病率显著相关。

Aim To study the relationship between plasma folic acid level and essential hypertension(EH)in Kazak of Shawan County,Xinjiang.Methods 641 Kazaks and 702 Han nationalities in Shawan County of Xinjiang were selected as research subjects,of which 654 were in EH group and 689 were in control group with normal blood pressure.General data of sex,age,body mass index,waist-hip ratio and biochemical indexes were collected.Blood samples were collected and plasma folic acid levels were measured by ACCESS automatic particle chemiluminescence immunoassay system.Results(1)The plasma folic acid level of Kazak was lower than that of Han nationality(P<0.01);The plasma folic acid level in EH group was lower than that in control group(P<0.01);The plasma folic acid level in males was lower than that in females(P<0.01).(2)After sex stratification,the plasma folic acid level in male Kazak EH group was significantly lower than that in control group(P<0.05),and the plasma folic acid level in female Han nationality EH group was significantly lower than that in control group(P<0.01).In Kazak population,plasma folic acid level in males was significantly lower than that in females(P<0.05).The plasma folic acid level of Kazak was significantly lower than that of Han nationality in both male and female(P<0.01).(3)The plasma folic acid level of EH group and control group was significantly lower in Kazak than that in Han nationality(P<0.01).In EH group and control group,the plasma folic acid level of Kazak was significantly lower than that of Han nationality,both male and female(P<0.05).Conclusions The plasma folic acid level of Kazak in Shawan County of Xinjiang is lower than that of Han nationality,and that of EH patients is lower than that of normal people.There is a significant correlation between plasma low folic acid level and high prevalence of EH in Kazak.