血管紧张素Ⅱ 1型受体基因多态性对动脉硬化影响的Meta分析

Meta-analysis of the effect of angiotensin Ⅱ type 1 receptor gene polymorphism on arteriosclerosis

目的研究血管紧张素Ⅱ1型受体基因(AGTR1) A1166C多态性对动脉硬化的影响。方法以脉搏波传导速度(PWV)为评价动脉硬化的指标。在Pub Med、EMBASE、Cochrane Library和Web of Science中检索与主题相关的英文文章。检索时限为建库至2018年10月。2位作者根据相应的纳入和排除标准独立选择合适的观察性研究。采用Revman 5. 2软件和STATA 11. 0软件进行Meta分析。结果共有7篇文章被纳入分析(n=1 687)。分析结果显示,在总体人群和白种人群中,AGTR1 A1166C多态性与PWV没有显著相关性;在亚洲人群中,等位基因C携带者的PWV显著高于AA基因型(AC+CC比AA:SMD=0. 33,95%CI 0. 06~0. 60,P=0. 02)。结论AGTR1 A1166C多态性可能与亚洲人的动脉硬化相关。等位基因C可能是亚洲人群PWV升高的危险因素。

Aim To study the effect of A1166 C polymorphism of angiotensinⅡtype 1 receptor gene(AGTR1 on arteriosclerosis.Methods Pulse wave velocity(PWV)was chosen as an index for evaluating arteriosclerosis.Topic-related English literatures were searched in Pub Med,EMBASE,Cochrane Library and Web of Science.The retrieval time was from the establishment of the database to October 2018.Two authors independently selected appropriate observational studies based on the corresponding inclusion and exclusion criteria.Revman 5.2 software and STATA 11.0 software were used for Meta-analysis.Results A total of seven literatures(n=1 687)was included in the Meta-analysis.The results showed that there was no significant correlation between AGTR1 A1166 C polymorphism and PWV in general population and white population.In Asian population,the PWV of allele C carriers was significantly higher than that of AA genotype(AC+CC vs AA:SMD=0.33,95%CI 0.06-0.60,P=0.02).Conclusions AGTR1 A1166 C polymorphism may be associated with arteriosclerosis in Asians.Allele C may be a risk factor for PWV elevation in Asian population.