内脏脂肪组织与心肌纤维化研究进展

Research progress of visceral adipose tissue and myocardial fibrosis

肥胖与心肌纤维化关系密切,尤其是内脏脂肪组织与心肌纤维化的相关性,引起了医学界的重视。既往有众多研究证实内脏脂肪组织通过分泌瘦素、脂联素等多种脂肪细胞因子参与心肌纤维化,其作用机制较为复杂。而最近研究表明内脏脂肪组织还能通过产生骨桥蛋白促进心肌纤维化。新兴起的测定内脏脂肪组织的生物电阻抗分析法亦将为其进一步的临床应用及研究奠定基础。文章就内脏脂肪组织参与心肌纤维化机制及其测定方法作一综述。

Obesity is closely related to myocardial fibrosis,especially the correlation between visceral adipose tissue and myocardial fibrosis,which has attracted the attention of the medical community.A number of studies have confirmed that visceral adipose tissue participates in myocardial fibrosis by secreting a variety of adipocytokines such as leptin and adiponectin,and its mechanism of action is complicated.Recent studies have shown that visceral adipose tissue can also promote myocardial fibrosis by producing osteopontin.The emerging bioelectrical impedance analysis method for measuring visceral adipose tissue will also lay the foundation for further clinical application and research.This article reviews the involvement of visceral adipose tissue in the production of myocardial fibrosis and its determination method.