摘要
中性粒细胞明胶酶相关脂质运载蛋白(NGAL)也被称为Lcn2,或癌基因24p3,是成熟嗜中性粒细胞特异性颗粒中储存的明胶酶复合的糖蛋白,也由其他细胞类型产生,包括心肌细胞。NGAL是急性肾损伤的早期生物标志物。最近发现NGAL可能是主要不良心血管事件和死亡率的独立预测因子,但关于NGAL与心血管疾病(CVD)的关系尚未达成一致,文章就NGAL与冠心病、高血压、心力衰竭的关系及NGAL与心血管疾病相关靶向治疗做一综述。
Neutrophil gelatinase-associated lipocalin(NGAL),also known as Lcn2(lipocalin 2),or oncogene 24 p3,is a gelatinase complex stored in mature neutrophil-specific particles.Glycoproteins are also produced by other cell types,including cardiomyocytes.NGAL is an early biomarker of acute kidney injury.Recently,NGAL has been found to be an independent predictor of major adverse cardiovascular events and mortality,but the relationship between NGAL and cardiovascular disease(CVD)has not been agreed.This article reviews the relationship between NGAL and coronary heart disease,hypertension and heart failure,and the targeted therapy of NGAL and CVD.
作者
张英
刘晓腾
金凤表
刘秋梅
刘慧卿
高宇
侯瑞田
ZHANG Ying;LIU Xiaoteng;JIN Fengbiao;LIU Qiumei;LIU Huiqing;GAO Yu;HOU Ruitian(Department of Cardioelectrophysiology,the Affiliated Hospital of Chengde Medical University,Chengde,Hebei 067000,China)
出处
《中国动脉硬化杂志》
CAS
2019年第10期915-920,共6页
Chinese Journal of Arteriosclerosis
基金
承德市技术研究与发展计划项目(201801A026)
关键词
NGAL
冠心病
高血压
心力衰竭
靶向治疗
NGAL
coronary heart disease
hypertension
heart failure
targeted therapy
