肝细胞生长因子在肿瘤侵袭转移中的作用
被引量:3
The role of hepatocyte growth factor in the invasion and metastasis of tumer
摘要
肝细胞生长因子 (HGF)是一种多功能的细胞因子 ,通过与其特异性受体c Met蛋白结合引发细胞内的信号传导途径 ,参与肿瘤的侵袭转移过程。对HGF及其受体在肿瘤侵袭转移过程中作用机制的研究为抗肿瘤转移治疗提供了一个极有希望的新靶点。
出处
《国外医学(肿瘤学分册)》
2003年第1期10-13,共4页
Foreign Medical Sciences (Cancer Section)
参考文献18
-
1Maulik G;Shrikhande A;Kijima T.Role of the hepatoeyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition[J],2002(01).
-
2Davies G;Jiang WG;Mason MD.Cell-cell adhesion molecules and signaling intermediates and their role in the invasive potential of prostate cancer cells[J],2000(03).
-
3Nakopoulou L;Gakiopoulou H;Keramopoulos A.c-Met tyrosine kinase receptor expression is associated with abnormal β-eatenin expression and favourable prognostic factors in invasive breast carcinoma[J],2000(04).
-
4Li G;Schaider H;Satyamoorthy K.Downregulation of Ecadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development[J],2001(56).
-
5Weimar IS;Jong D;Muller EJ.Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via α4β1 and a5β1 integrins[J],1997(03).
-
6Trusolino L;Cavassa S;Angelini P.HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity[J],2000(11).
-
7Kermorgant S;Aparicio T;Dessirier V.Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement[J],2001(07).
-
8YanoH;HaraA;MuralS;etal.Expression of hepatocyte growth factor and matrix metalloproteinase-2 in human glioma,2001(01).
-
9Ried S;Jager C;Jeffers M.Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor[J],1999(23).
-
10Okusa Y;Ichikura T;Mochizuki H.Urokinase type plasminogen activator and its receptor regulate the invasive potential of gastric cancer cell lines,2000(05).
同被引文献13
-
1黄维亮,谢元林,常伟红,邓春明,肖新强.紫河车促肝细胞生长的研究[J].中西医结合肝病杂志,2004,14(6):357-359. 被引量:6
-
2谢元林,常伟宏,黄维亮,苏先狮.人胎盘提取物对实验性肝损伤保护作用的观察[J].中国医师杂志,2005,7(4):507-508. 被引量:3
-
3侯俐,方肇勤.原发性肝癌的辨证论治进展[J].河南中医,2007,27(2):78-81. 被引量:17
-
4Weimar I S, Jong D, Muller E J, et al. Hepatoeyte growth factor/scatter factor promotes adhesion of lymphoma ceils toextracellular matrix molecules via α4β1 and α5β1 integrins [ J ]. Blood, 1997,89(3) :900 - 1000.
-
5郭连英,施广霞,赵雅莉.IL-6治疗小鼠肝癌的实验研究[J].大连医科大学学报,1997,19(2):99-100. 被引量:1
-
6徐淑云 卞如廉 陈修.药理实验方法学[M]:第2版[M].北京:人民出版社,1994.1757-1767.
-
7成建山.中药外治的现状与展望.中医药杂志,1992,33(12):40-40.
-
8Holmes O, Pillozzi S, Deakin JA, et al. Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains. J Mol Biol,2007,367 (2) :395-408.
-
9潘继存,徐新,江森,刘伟国.卵巢癌患者血清及腹水白细胞介素6测定的临床意义[J].中国免疫学杂志,1997,13(4):242-244. 被引量:13
-
10李增生,张可成,杨辉,王雪梅.白细胞介素-6mRNA在脑肿瘤的表达及其意义[J].中国肿瘤临床,1999,26(3):185-187. 被引量:17
引证文献3
-
1田水,周艳丽.“治癌灵”穴贴及针刺对H_(22)肝癌小鼠HGF表达的影响[J].辽宁中医药大学学报,2007,9(5):173-175.
-
2谢元林,常伟红,黄维亮,喻友军,苏先狮,邓春明,肖新强.人肝细胞生长因子真核质粒的克隆及活性测定[J].中国医师杂志,2007,9(11):1483-1484.
-
3刘瑞,周艳丽.“治癌灵”穴贴及针刺对H_(22)肝癌小鼠抑癌作用的影响[J].河南中医,2009,29(12):1176-1178. 被引量:1
二级引证文献1
-
1吴春晓,钟广恩,周国平,杨路,詹珠莲,陈凤,许秀洪,王娇,兰晓.针灸抗肿瘤作用的实验研究概况[J].中国中医基础医学杂志,2016,22(7):1011-1012. 被引量:5
-
1申兴斌,王瑞婷,梅爱敏,金小平,张文斌.VEGF及MMP-7与大肠癌的关系[J].肿瘤防治研究,2007,34(6):442-445. 被引量:2
-
2申兴斌,金小平,王瑞婷,李瑞香,于再东.VEGF及其受体Flk-1在大肠癌中表达的意义[J].陕西医学杂志,2007,36(3):300-302. 被引量:6
-
3申兴斌,王瑞婷,金小平,于再东.基质金属蛋白酶7在大肠正常黏膜、腺瘤及癌组织中的表达[J].肿瘤防治研究,2005,32(10):627-629.
-
4王琨.基质金属蛋白酶-2与恶性肿瘤[J].社区医学杂志,2009,7(9):25-26.
-
5杨威,李凡,李胜文.抗肿瘤转移治疗的研究新进展[J].国外医学(泌尿系统分册),2000,20(3):133-135. 被引量:1
-
6王瑞婷,申兴斌,张泓波.VEGF在大肠癌中的表达及意义[J].山东医药,2006,46(35):57-58. 被引量:7
-
7张瑰红,杨文涛,施达仁.肿瘤淋巴管形成的研究进展[J].国际肿瘤学杂志,2005,32(1):6-10. 被引量:1
-
8张建平,谢幸,吕卫国.趋化因子与肿瘤的定向转移[J].国外医学(肿瘤学分册),2005,32(5):351-354. 被引量:8
-
9王瑞婷,申兴斌,梅爱敏,金小平,张文斌.基质金属蛋白酶-7和血管内皮生长因子与大肠癌进展及预后的关系[J].广东医学,2006,27(9):1319-1322. 被引量:2
-
10王瑞婷,张文斌,申兴斌,金小平.基质金属蛋白酶-7及血管内皮生长因子在大肠癌组织中的表达及意义[J].山东医药,2007,47(35):23-25. 被引量:1