缺氧缺血性脑病新生儿血浆神经肽Y和降钙素基因相关肽的变化

Changes of Serum Neuro Peptide Y and Calcitonin-Gene Related Peptide in Neonates with Hypoxic-Ischemic Encephalopathy

目的 研究缺氧缺血性脑病新生儿血浆神经肽Y(NPY)和降钙素基因相关肽(CGRR)的变化。方法 采用放免法动态观察42例中度HIE患儿和30例正常对照组NPY和CGRP在急性期和恢复期的变化以及与脑血流的相关性。结果 观察组NPY总体水平高于对照组,尤以窒息后第2,3天为著[(168.3±10.9)ng/L vs(86.7±5.4)ng/L],差异有显著性(P<0.01);观察组CGRP总体水平低于对照组,尤以窒息后第2,3天为著[(48.4±3.7)ng/L vs(81.3±16.8)ng/L],差异有显著性(P<0.01)。结论 NPY,CGRP在HIE的发病机理中可能起重要的作用,参与了HIE的发生和发展;HIE第2～3天脑血管痉挛收缩,是应用扩血管治疗的最佳时期。

Objective To study the dynamic changes of serum neuro peptide Y (NPY) and calcitonin-gene related peptide (CGRP) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Forty-two neonates with HIE (Group A) and 30 normal neonates (controls, Gruop B) were enrolled in this research. Their serum contents of NPY and CGRP were measured with the radio-immuno-assay, and the cranial blood flow was recorded at the same time. Results The serum NPY content in Group A was significantly higher than that in Group B, especially on day 2 to day 3 following asphyxia [(168.3±10.9) ng/L vs (86.7±5.4) ng/L]( P <0.01). The serum CGRP content in Group A was lower than that in Group B, especially on day 2 to day 3 after asphyxia [(48.4± 3.7) ng/L vs (81.3±6.8) ng/L] ( P <0.01). Conclusions NPY and CGRP might be important factors in the development of HIE. The dynamic measures of NPY and CGRP contents might be useful in determining the clinical management of HE. [Chin J Comtemp Pediatr, 2003, 5(1): 27 - 28]