吸入一氧化氮对持续肺高压新生儿血小板聚集功能的影响

Effect of Nitric Oxide Inhalation on Platelet Aggregation in Neonates with Persistent Pulmonary Hypertension

目的 探讨一氧化氮(NO)吸入治疗新生儿肺高压(PPHN)过程中血小板聚集功能的变化。方法采用比浊法测定PPHN患儿吸入NO 6h后血小板在肾上腺素、胶原和二磷酸腺苷(ADP)诱导下的聚集率。结果3种诱导剂引起血小板聚集的作用均明显受到抑制,与对照组相比分别为(0.39±0.11)％vs(0.48±0.10)％;(0.41±0.19)％vs(0.69±0.22)％;(0.32±0.12)％vs(0.50±0.16)％,差异均有显著性(P<0.05或0.01)。结论 PPHN患儿吸入NO后,血小板聚集能力明显受到抑制,存在加重临床出血的可能性。

Objective To study the effect of nitric oxide (NO) inhalation on platelet aggregation in neonates with persistent pulmonary hypertension. Methods The platelet aggregartion rate with the induction of epinephrine, collagen and adenosine diphosphate (ADP) was assayed by turbidimetry 6 hours after NO inhalation in 11 neonates with persistent pulmonary hypertension (NO inhalation group). Twelve neonates with this disorder receiving oxgen inhalation served as the controls. Results The platelet aggregation rate with the induction of epinephrine, collagen and ADP was significantly inhibited in the NO inhalation group compared with the controls: (0.39 ±0.11)% vs (0.48±0.10)%, (0.41±0.19)% vs (0.69 ± 0.22)%, (0.32±0.12)% vs (0.50 ± 0.16)%, respectively ( P <0.05 or 0.01). Conclusions NO inhalation may restrain platelet aggregation and increase hemorrhage risk.