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溶血磷脂酸与缺血性(心)脑卒中 被引量:23

Lysophosphatidic acid and ischemic stroke
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摘要 近年的研究发现 ,溶血磷脂酸 (LPA)等磷脂在心脑卒中的发生过程中起重要作用。而且可能作为血栓形成前的一种释放物 ,预警血栓形成的可能发生。本文从缺血性脑卒中的预防和预警及溶血磷脂酸的作用 。 In recent years, it is found that lysophosphatidic acid plays an important role in cardic and cerebral ischemic attack. As an early product of thrombosis, it may also be used as an indicator for thrombophilia. This paper reviews the research progresses in the recent years especially the potential use of LPA in clinical diagnosis.
出处 《基础医学与临床》 CSCD 北大核心 2003年第1期1-4,共4页 Basic and Clinical Medicine
基金 国家科技部重点基础研究发展规划项目 (G2 0 0 0 0 5 6 90 5 )
关键词 溶血磷脂酸 心脑血管病 lysophosphatidic acid cardiovascular and cerebrovascular diseases
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  • 1Moolenaar WH. Lysophosphatidic acid,a multifunctional phospholipid messenger. J Biol Chem,1995, 270: 12949-12952.
  • 2Tokumura A, Iimori M, Nishioka Y, et al. Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta. Am J Physiol,1994, 267: C204-210.
  • 3Jalink K, Hordijk PL, Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator. Biochim Biophys Acta,1994, 1198: 185-196.
  • 4Xu Y, Shen Z, Wiper DW, et al. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers JAMA, 1998,280: 719-723.
  • 5Eichholtz T,Jalink K,Fahrenfort I,et al. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J,1993, 291 : 677-680.
  • 6Torti M, Tolnai Festetics E, Bertoni A, et al. Activation of human platelets by lysophosphatidic acid. Blood Coagul Fibrinolysis,1996,7: 253-255.
  • 7Zhang J, Rittenhouse SE. Lysophosphatidic acid activates phosphoinositide 3-kinase and phospholipase C in human platelets: inhibitory effects of wortmannin on phosphoinositide 3-kinase and aggregation. Biochem Biophys Res Commun,1995, 211: 484-490.
  • 8Gueguen G, Gaige B, Grevy JM,et al. Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. Biochemistry,1999,38: 8440-8450.
  • 9Gerrard JM, Robinson P.Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochim Biophys Acta, 1989, 1001: 282-285
  • 10Gerrard JM,Robinson P,Narvey M,et al. Increased phosphatidic acid and decreased lysophosphatidic acid in response to thrombin is associated with inhibition of platelet aggregation,Biochem Cell Biol,1993, 71: 432-439.

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