摘要
[目的]为进一步明确灯盏细辛药材药效作用的物质基础。[方法]本文采用硅胶、聚酰胺柱层析和重结晶等方法灯盏细辛乙醚提取物进行分离,并根据化合物的理化性质及1H-NMR、13C-NMR、HMBC、HR-MS等方法分析、鉴定化合物结构。[结果]从灯盏细辛乙醚提取部位中分离和鉴定出4个化合物,24(s)-3β-羟基豆甾-5-烯-7-酮(化合物1)、染料木素(化合物2)、3’,4’-二甲氧基槲皮素(化合物3)、β-谷甾醇(化合物4)。其中化合物1、2均为首次从灯盏细辛药材中分离得到。[结论]研究结果丰富了灯盏细辛的化学成分内容,为今后的开发提供了科学依据。
[Objective]To further determine the material basis of the pharmacodynamics of Erigeron breviscapus.[Method]the chemical constituents were repeated by silica,gelpolyamide column chromatography and recrystallization,and the structures of compounds from the ether extraction were identified on the basis of physico-chemical characteristics by1 H-NMR,13 C-NMR,HMBC,HR-MS spectrum.[Result]4 compounds were isolated and elucidated from the ether extraction from Erigeron breviscapus,which were 24(s)-3β-hydroxystigmast-5-en-7-one(1),genistein(2),3’,4’-trimethoxyquercetin(3),β-sitosterol(4).[Conclusion]Compound 1 and 2 were separated from Erigeron breviscapus for the first time.The results not only enriched its chemical constituents of Erigeron breviscapus,but also would provide material basis for its development in the future.
作者
李君
Li Jun(XiangTan Medicine and Health Vocational College HunanXiangtan 411102)
出处
《科技风》
2019年第25期150-151,共2页
关键词
灯盏细辛
乙醚部位
组分分离
首次
结构鉴定
Erigeron breviscapus
ether extraction
constituent isolation
first time
structure identification