甲状腺及生殖系统多原发癌临床分析

A Clinical Analysis of Multiple Primary Carcinomas in Thyroid and Genital Systems

目的探讨甲状腺及生殖系统多原发癌的临床特点.方法回顾性分析2009年1月至2012年1月收治的甲状腺及生殖系统多原发癌患者的临床资料.结果昆明医科大学第三附属医院头颈外科共收治甲状腺及生殖系统多原发癌患者38例,其中乳腺与甲状腺多原发癌19例,宫颈与甲状腺多原发癌11例,卵巢与甲状腺多原发癌6例,子宫内膜与甲状腺多原发癌2例.19例乳腺癌中导管癌12例、小叶癌7例,雌激素受体阳性17例.11例宫颈癌中鳞癌10例、腺癌1例,HPV均为阳性,雌激素受体阳性8例.6例卵巢癌及2例子宫内膜癌均为腺癌,雌激素受体阳性例数分别为4例和2例.38例甲状腺癌中,乳头状癌33例,滤泡状癌5例,雌激素受体阳性21例.结论甲状腺及生殖系统多原发癌中最常见的是甲状腺-乳腺多原发癌,其次是甲状腺-宫颈多原发癌;甲状腺及生殖系统多原发癌的发生可能与雌激素受体相关;临床上对生殖系统恶性肿瘤患者行甲状腺超声检查有助于甲状腺癌的早期诊断和早期治疗.

Objective To probe the clinical characteristics of multiple primary carcinomas in thyroid and genital systems. Methods A retrospective analysis was performed in patients with thyroid and genital system cancers from 2009 to 2012. Res ults There were 38 cases suffered with genital system cancers and thyroid carcinomas from 2009 to 2012,including 19 breast cancers,11 cervical cancers,6 ovarian cancers and 2 endometrial carcinomas. There were 12 duct cancers and 7 lobular carcinomas in 19 breast cancers,including 17 ER positive cases. There were 10 squamous cell carcinomas and 1 adenocarcinoma in 11 cervical cancers with HPV positive,including 8 ER positive cases. 6 ovarian cancers and 2 endometrial carcinomas were all adenocarcinomas, and ER positive cases were 4 and 2 respectively. There were 33 papillary carcinomas and 5 follicular carcinomas in 38 thyroid cancers, including 21 ER positive cases. Conclus ion Breast cancers and thyroid carcinomas are the most common multiple primary carcinomas in genital system, following with cervical and thyroid cancers. Their pathogenesis may be concerned with estrogen receptor. Taking ultrasonic inspection in the patients with genital system neoplasms may profit the early diagnosis and therapy of thyroid carcinomas.