IL-6,IL-10在实验性肺部炎症中的研究进展

Advanced on IL-6 and IL-10 in Experimental Pneumonia

炎症是具有血管系统的生活机体对损伤因子所发生的复杂的防御反应,病理上表现为不同程度的中性粒细胞及单核细胞、淋巴细胞浸润.肺炎时,致炎因子激活中性粒细胞和单核细胞后可释放一系列细胞因子如TNF-α、IL-6、IL-8等,促进炎症反应和组织损伤;同时机体可释放具有抗炎和免疫调节作用的细胞因子如IL-10等.促炎因子和抗炎因子水平的动态变化在参与调控炎症反应系统与抗炎反应系统中发挥重要作用,而IL-6与IL-10是研究较多的促炎因子与抑炎因子之一,就两者与肺部感染性疾病的研究进展进行综述.

Inflammation is the complex defensive reaction of living organism with a vascular system to the injury factors, which pathologically manifests as different levels of neutrophils, monocytes and lymphocytes infiltrating.When catch pneumonia, inflammatory factors activate the neutrophils and monocytes first, then release a series of cytokines such as TNF-α,IL-6 and IL-8 to promote inflammation and tissue injury. At the same time, the body will release cytokines with anti-inflammatory and immunomodulatory effect such as IL-10, etc. Recent studies have suggested that the dynamic changes of inflammatory and anti-inflammatory cytokines play an important role in the regulation of inflammatory response system. This review focuses on the effects of IL-6 and IL-10 in the pulmonary infectious diseases which have been studied extensively at present.