CAF方案和CAP方案治疗晚期乳腺癌疗效

The efficacy study of regimen CAF and CAP for the treatment of advanced breast carcinoma.

目的 比较CAF方案和CAP方案治疗晚期乳腺癌的疗效以及毒性反应。方法 选择 42例晚期乳腺癌患者随机分为两组 ,A组接受CAF方案治疗 (CTX、ADM、FUDR)。B组接受CAP方案治疗(CTX、ADM、DDP)。结果 A、B两组有效率分别为 6 8 1%和 6 0 0 % ,无显著性差异 (P >0 .0 5 ) ;两组毒性反应主要是骨髓抑制、消化道反应和心脏毒性 ,而消化道反应A组明显低于B组有显著性差异 (P<0 .0 1)。结论 CAF方案和CAP方案均为治疗晚期乳腺癌的有效方案 ,但CAF方案的毒性小 ,病人易于耐受。

Objective To compare the efficacy and toxicity of regimen CAF with regimen CAP. Methods Forty two cases with advanced breast carcinoma were selected and divided to two groups randomly. Group A was treated with regimen CAF(CTX, ADM,FUDR). Group B was treated with regimen CAP(CTX, ADM,DDP). Results The response rate of group A was 68.1%, The response rate of group B was 60.0% (P>0.05). The major toxicities were bone marrow suppression, nausea and vomiting, heart toxicity.Conclusion The regimen CAF and CAP for the advanced breast carcinoma have got the same efficacy, but the toxicity of regimen CAF is lower.