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Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice 被引量：1

Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice
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摘要 Objective: To examine the role of recombinant adenovirus vector containing CTLA4Ig gene(Ad-CTLA4Ig) in the treatment of induced allergic rhinitis in mice.Methods: Allergic rhinitis was induced by sensitizing and challenging with ovalbumin(OVA).Ad-CTLA4Ig was intraperitoneally injected 30 min before OVA challenge.Adenovirus vector without inserted CTLA4Ig cDNA served as the control.The symptoms and morphological changes of nasal mucosa of each group were observed, and the serum levels of IgE against OVA were detected with ELISA.Results: There were no obvious symptoms and pathological changes in Ad-CTLA4Ig treated group, in which the serum OVA-specific IgE levels were significantly lower than that in control groups(P< 0.05).Conclusion: Ad-CTLA4Ig prevents and treats allergic rhinitis of mice,implying the possibility of the usage of Ad-CTLA4Ig against allergic rhinitis in clinic in future. Objective: To examine the role of recombinant adenovirus vector containing CTLA4Ig gene( Ad-CTLA4Ig) in the treatment of induced allergic rhinitis in mice. Methods: Allergic rhinitis was induced by sensitizing and challenging with ovalbumin ( OVA). Ad-CTLA4Ig was intraperitoneally injected 30 min before OVA challenge. Adenovirus vector without inserted CTLA4Ig cDNA served as the control. The symptoms and morphological changes of nasal mucosa of each group were observed, and the serum levels of IgE against OVA were detected with ELISA. Results: There were no obvious symptoms and pathological changes in Ad-CTLA4Ig treated group, in which the serum OVA-specific IgE levels were significantly lower than that in control groups (P < 0. 05). Conclusion: Ad-CTLA4Ig prevents and treats allergic rhinitis of mice, implying the possibility of the usage of Ad-CTLA4Ig against allergic rhinitis in clinic in future.
作者 朱瑾 吴军 陈希炜 易绍萱 罗高兴 贺伟峰
机构地区 Department of Otolarynology Institute of Burn Research
出处 《Journal of Medical Colleges of PLA(China)》 CAS 2003年第1期15-18,共4页 中国人民解放军军医大学学报（英文版）
基金 Supported by the National Natural Science Foundation of China(No.39993430-2) Key Project of Ministry of Science and Techology(No.96-920-20-10) Academician Foundation of Chongqing (No.96-901-05-18) Tackling Key Project of 1999(No.1999-6-40)
关键词 recombinant CTLA4Ig adenovirus vector allergic rhinitis IGE 小白鼠 变应性鼻炎 重组CTLA4Ig 腺病毒载体 基因治疗
分类号 R765.21 [医药卫生—耳鼻咽喉科] R394.8 [医药卫生—医学遗传学]
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Journal of Medical Colleges of PLA(China)
2003年 第1期

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