N,N-二甲胺基硫代乙酰胺的合成研究

Synthesis of dimethylaminothioacetamid

目的 :研究尼扎替丁中间体N ,N -二甲胺基硫代乙酰胺的合成 ,考察不同反应温度、反应时间对收率的影响。方法 :采用硫氢化钠为催化剂 ,硫化氢气体直接通入原料N ,N -二甲胺基乙腈中反应 ,然后通过过滤、减压蒸馏得粗品 ,用异丙醇重结晶得成品。结果 :控制反应温度约 5 0℃ ,通入硫化氢气体反应 6小时。结论 :该合成方法为N ,N-二甲胺基硫代乙酰胺的工业化生产提供了一条新途径。

Aim:To synthesis dimethylaminothioacetamid,one of the intermediates of nizatidine and investigate the effects of different reaction temperature and time on yields.Methods:Sodium hydrosulfide was used as a catalyst.Hydrogen sulfide gas was bubbled into the raw material of dimethylaminothioacetonitrile,followed by filtration and distillation in vacuum to get the crude product.Then the crude product was purified by re-crystallization.Results:The temperature was controlled at 50℃.The hydrogen sulfide gas was bubbled for 6 h.Conclusion:It is a new route for industrial production of dimethyl-aminothioacetamid.