白芍提取物对IgA肾炎小鼠的治疗作用

The Effect of the Extract from Radix Paeoniae Alba on IgA Glomerulonephritis in Mice

目的:观察白芍提取物对小鼠IgA肾炎的治疗作用。方法:用右旋糖酥(Dextran)作为抗原,诱发小鼠IgA肾炎,同时用白芍提取物进行实验性治疗,测定尿蛋白含量、血清尿素氮(BUN)、肌酐(SCr)的含量。结果:小鼠注射抗原后,出现蛋白尿,血清BUN出现异常,用白芍提取物治疗后,可抑制小鼠体重减轻,并能显著降低尿蛋白的含量(P<0.01),白芍提取物10g/kg组还能明显降低血液中BUN的含量(P<0.05)。结论:白芍提取物对小鼠IgA肾炎有一定治疗作用。

Obiective:To observe the effect of the extract from Radix Paeoniae Alba on IgA glomerulonephritis in mice. Methods: IgA glomerulonephritis was induced by injection of dextran and sephadex-150. After administrating the extract, the contents of urinary protein, BUN and Cr in serum were determined. Results:The extract could inhibit the decline of mouse weight, and decrease urinary protein content and BUN content in serum.While, the extract had no effect on Cr in serum.Conclusion:The extract from Radix Paeoniae Alba had therapeuticaal effect on IgA glomerulonephritis.