保肝康对急性肝损伤大鼠肝细胞凋亡的影响

Inhibitory Effect of Bao gan kang on Hepatocellular Apoptosis in Rats with A-cute Liver Injury

目的:探讨保肝康抗肝损伤的作用机理。方法:采用D-GlaN所致大鼠急性肝损伤模型,观察保肝康对此模型肝细胞凋亡及相关基因表达的影响。结果:①保肝康有抑制肝细胞凋亡的作用。②Fas/FasL的表达率与肝细胞凋亡呈平行相关。结论:①保肝康抑制肝细胞凋亡的作用是其抗肝损伤的作用机理之一。②保肝康抑制肝细胞凋亡作用机理可能是下调Fas/FasL的表达。

Objective: To study the mechanism of Baogankang (BGK) preventing acute liver injury. Methods: The a-cute liver injury model of rats was induced by D-galactosamine (D-GlaN), and the inhibitory effect of BGK on hepatocellular apoptosis and the expression of Fas and FasL in the model were observed. Results: ①BGK could markedly inhibite apoptosis of liver cell. ②There was positive correlation between Fas and FasL expression and hepatocellular apoptosis. Conclusion: ①It was suggested that BGK had an effect on inhibiting apoptosis which was one of the mechanism of BGK preventing liver injury. ②Downregulating the level of Fas and FasL expression was probably one mechanism of BGK inhibiting apoptosis.