氟桂利嗪辅助治疗脑梗死后继发的早期癫痫

Flunarizine in adjuvant treatment of early epilepsy patients after cerebral infarction

目的 :探讨氟桂利嗪辅助治疗脑梗死后继发的早期癫痫的临床机制和治疗效果。方法 :脑梗死后继发的早期癫痫的病人 92例 ,随机分为治疗组4 7例 ,对照组 4 5例 ,对照组按不同的发作类型分别服用苯妥英、丙戊酸纳、卡马西平及地西泮等药 ;治疗组则在此基础上加服用氟桂利嗪胶囊 ,每日 5mg ,qn ,疗程 3mo。治疗后进行疗效评定。治疗前后对血液流变学、血脂、肾功能等生化指标进行对比性分析。结果 :治疗后 ,治疗组抗癫痫疗效优于对照组 ,经Ridit分析 ,差异有非常显著意义 (P <0 .0 1)。治疗组治疗后凝血因子I、血小板粘附率 ,凝血酶原时间 ,分别为 (2 .8±s 0 .7) g·L- 1,(5 2± 3) % ,(16.7± 2 .0 )s与对照组比较 ,(3.6± 0 .7) g·L- 1,(5 6± 3) % ,(14.9± 2 .2 )s ,差异有显著意义或非常显著意义 (P <0 .0 5或P <0 .0 1)。结论

AIM: To evaluate the effect of flunarizine on early epilepsy patients after cerebral infarction(CI). METHODS: Ninety two early epilepsy patients wiht CI were randomly divided into two groups, the flunarizine treating group( n =47) and the control group( n =45). Roution treatment was given to all patients. The control group was given carbamazepine phenytoin sodium valproate or diazepam differently, and on the basis of this, flunarizine 5 mg,qn,for three months was given to the treating group. RESULTS: After three months therapy, the treating group showed better than the control group in the antiepileptic effect by Ridit analysis( P <0.01). After treatment the fibrinogen, platelet adhesiveness rate and prothrombin time in treating group was(2.8± s 0.7)g·L -1 ,(52±3)%,(16.7±2.0)s, respectively, compared with control group ((5.6±0.7)g·L -1 ,(56±3)%,(14.9±2.2)s). There was significant difference( P <0.01). CONCLUSION: Flunarizine is effective in adjuvant treatment of early epilepsy patients after cerebral infarction.