聚乳酸-羟基乙酸在骨组织工程支架材料中的应用

Application of poly(lactic-co-glycolic acid) in bone tissue engineering scaffolds

因外伤、肿瘤等多种原因造成的骨组织缺损需要良好的骨组织替代物修复。随着骨组织工程的不断发展,为骨缺损的修复带来了新思路。学者们一直致力于研发与改性各种骨组织工程支架材料以更好地帮助修复骨缺损。聚乳酸-羟基乙酸因具有良好的生物降解性、生物相容性等优点而备受关注。本文仅对近年来在骨组织工程中聚乳酸-羟基乙酸支架材料的改性与设计进行简要综述。

Bone defect caused by trauma,tumor or other causes needs suitable substitute bones to repair.The continuous development of bone tissue engineering brings new ideas to the repair of bone defect.Scientists have been making efforts in developing and optimizing all sorts of scaffold materials for bone tissue engineering to better help repair bone defect.Poly(lactic-co-glycolic acid)has attracted much attention because of its good biodegradability,biocompatibility and other advantages.This paper focuses on reviewing recent studies on design and modification of poly(lactic-co-glycolic acid)scaffold materials in bone tissue engineering.