病毒感染在口腔鳞状细胞癌中的病因学作用

Etiological role of virus infection in oral squamous cell carcinoma

口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是上皮来源口腔恶性肿瘤中最常见的一种,其病因为遗传、环境、感染等多因素的相互作用。随着烟酒等经典因素的逐年减少,病毒感染在OSCC发生发展中的作用愈发重要。现已确认人类乳头状瘤病毒(human papillomavirus,HPV)是OSCC发生的危险因素之一,另有部分学者认为,EB病毒(Epstein-Barr virus,EBV)、单纯疱疹病毒I型(herpes simplex virus 1,HSV-1)、人类巨细胞病毒(human cytomegalovirus,HCMV)、人类疱疹病毒6型(human herpes virus-6,HHV-6)、丙型肝炎病毒(hepatitis C virus,HCV)等多种病毒也具有口腔致癌能力,但这些观点尚存争议。该文回顾了近些年的相关文献,旨在揭示病毒感染对OSCC的病因学作用,并为未来的研究提供参考思路。

Oral squamous cell carcinoma(OSCC)is one of the most common oral epithelial malignant tumors.Its etiology is commonly concerned as interactions of genes,environment,infection and other multi-factors.Human papillomavirus has been identified as one of the risk factors for the occurrence of OSCC,while some other scholars believe that Epstein-Barr virus,herpes simplex virus type I,human cytomegalovirus,human herpes virus-6,hepatitis C virus and other viruses can also cause oral cancer,but these views are still controversial.This article reviews the literature in recent years to reveal the etiological role of viral infections in OSCC and provide ideas for future research.