水通道蛋白5在唾液腺分泌中的作用及其临床应用

The role and clinical application of AQP5 in salivary gland secretion

水通道蛋白5(AQP5)是一种能特异性跨膜转运水的蛋白,能显著增加细胞膜水通透性,参与水的分泌与吸收,并保持细胞内外的水平衡,在人体的外分泌功能中具有关键作用。近年来的研究发现,唾液腺分泌与AQP5的表达与定位有着不可分割的关系,临床上将AQP5作为治疗唾液腺分泌障碍的作用靶点取得了可观的治疗效果。该文就AQP5的结构、功能及其在唾液腺分泌中的作用及临床应用作一综述。

Aquaporin 5(AQP5)is a protein that can specifically transport water across membranes.It can significantly increase cell membrane water permeability,participate in water secretion and absorption,and maintain water balance inside and outside the cells.It plays a key role in human external secretion function.Recent studies have found that salivary gland secretion is inseparably related with the expression and localization of AQP5.AQP5 is clinically used as a target for the treatment of salivary gland secretion disorders,which has achieved considerable therapeutic effects.This article reviews the structure and function of AQP5 as well as its role in salivary gland secretion and clinical application.