程序性死亡分子1信号途径与牙周炎相关性的研究进展

Research progress of the relationship between programmed death 1 signaling pathway and periodontitis

牙周炎是人类口腔的常见病,免疫机制在牙周炎的发生发展中有非常重要的作用。程序性死亡分子1(programmed death 1,PD-1)及其配体是近年发现的参与免疫抑制作用的重要分子,在牙周炎患者的外周血淋巴细胞、牙周膜成纤维细胞、牙龈上皮细胞上均有表达,该文将就PD-1信号途径与牙周炎的相关性作一综述。

Periodontitis is a common oral disease in human.The immune mechanism plays an important role in the development of periodontitis.In recent years,it has been found that programmed death 1(PD-1)and its ligands are important molecules involved in immunosuppression.It has been demonstrated that the molecules involved in PD-1 signaling can be expressed on peripheral blood lymphocytes,periodontal ligament fibroblasts and gingival epithelial cells in patients with periodontitis.This article is to discuss the correlation between PD-1 signaling pathway and periodontitis.