麦冬多糖Md-1、Md-2化学结构的研究

Structural Features of Two Neutral Polysaccharides Md-1, Md-2 firom Ophiopogon japonocus

目的:研究中药麦冬中的多糖化学结构。方法:采用柱层析进行纯化,并用红外光谱和核磁等方法阐明Md-1、Md-2的化学结构。结果:两多糖分子量为27064、48651,均由单一的葡萄糖组成,构型为α型,单糖的连接方式为1→4连接。结论:Md-1、Md-2多糖的化学结构均为有一取代甲基的α-D-(1→4)的葡聚糖,两多糖的硫基含量和分子量不同。

Objective: To study the chemical feature of Md-1, Md-2 polysaccharides which extracted from Ophiopogon japonocus. Method: Two constituents were isolated and purified by gel-filtration chromatography. Physicochemical constants and spectral analysis further were used to study their structural features. Result: The mean molecular weights were estimated to be 27064 and 48651. Structures were composed of D-glucose.Conclusion: Md-1 and Md-2 polysaccharides are glucosans, which only are composed of D-glucose units joined by a-(1-4) glucosidic linkages.