年龄、绝经年限与骨代谢指标相关性研究

Study on Correlation Among Age,Menopausal Years and Bone Metabolite Index

目的 :探讨妇女不同年龄段、绝经年限、初潮年龄的骨代谢指标的变化。方法 :随机选择年龄 2 0～ 75岁的妇女 2 10例 ,测定血清钙 (Ca)、磷 (P)、碱性磷酸酶 (ALP)、性激素 ,尿钙 /肌酐 (Ca/Cr)值。结果 :骨代谢指标与年龄、绝经年限、初潮年龄均呈正相关 ,40岁以上的妇女的骨代谢指标明显高于 40岁以下的妇女 (P <0 0 5 ) ;初潮年龄在 18岁以上的妇女骨代谢指标明显增高 (P <0 0 5 ) ;绝经后E2 水平较绝经前降低 (P <0 0 5 ) ,但不同绝经年限间差异无显著性 (P >0 0 5 ) ;绝经后骨代谢指标较绝经前增高 (P <0 0 5 ) ,尤其在绝经后 10年以上增高更明显。结论 :妇女在围绝经早期出现骨转换率增高 ,可能与雌激素下降有关 ,因此对围绝经早期妇女 ,尤其是初潮年龄晚者 ,应进行骨代谢指标测定 。

Objective:To investigate the relationship of bone metabolite indexes with women’s age,menopausal time,and menarche age.Methods: 210 women at 20～75 years were randomly chosen to determining the bone metabolite indexes which included serum calcium(CA),phosphorus(P),alkaline phosphatase(ALP),sex hormone,and urine ratio of Ca/Creatine(Cr).Results: There was a positive correlation between bone metabolite indexes and women’s age,menopausal time,and age of menarche.The indexes in women over 4o years were higher than those of women under 40(P<0.05),also in women whose menarche age was under 18 years(P<0.05).Serum concentration of E 2 was lower in post-menopausal women than pre-menopausal women,but not related with menopausal time(P>0.05).The bone metabolite indexes increased after menopause,especially in women with menopause time lasted over 10 years(P< 0.05).Conclusions: Bone turnover increased in women during early menopause,which related to decrement of E 2 levels.It’s necessary to betecting bone metabolite indexes in early period of menopause and in women with earlier menarche age.Thus we can screening and prevent osteoporosis.