软肝冲剂对肝炎肝硬化门脉高压患者血清一氧化氮、内皮素的影响

Effect of Ruangan Granule on Serum NO and ET of Hepatic Cirrhosis Patients with Portal Hypertension

目的:观察软肝冲剂对肝炎肝硬化门脉高压患者门静脉主干内径及血流量、血流速度和血清一氧化氮(NO)、内皮素(ET)的影响。方法:选择肝炎肝硬化门脉高压患者97例,随机分为两组,治疗组口服软肝冲剂,对照组以西药常规治疗,观察治疗后的总有效率、肝功能、门静脉主干内径及血流量、血流速度和血清NO、ET的变化。结果:经治疗后治疗组总有效率优于对照组(P<0.05),患者ALT、TBil明显降低,Alb和A/G均明显升高,门静脉内径变窄、血流量增多、血流速度变快,同时NO及ET亦显著降低,与对照组比较,差异有显著性意义(P<0.05或0.01)。结论:软肝冲剂治疗肝炎肝硬化门脉高压疗效显著,能明显改善肝功能,降低门静脉压力,其作用机制之一是降低血清NO、ET水平。

Objective: To observe the effect of Ruangan Granule on inside diameter, blood stream capacity and speed of portal vein and serum NO and ET of hepatic cirrhosis patients with portal hypertension. Methods: 96 hepatic cirrhosis patients with portal hypertension were diveded into two groups randomly, the therapeutic group treated by Ruangan Granule, the control group treated by general treatment. After treatment, total efficiency rate, the indexes of liver function, inside diameter, blood stream capacity and speed of portal vein and the level of NO, ET were detected. Results: The total efficiency rate of the therapeutic group was better than that of control group (P<0.05). ALT, TBil were obviously decreased and Alb, A/G increased distinctly. Inside diameter of portal vein became narrow, and blood stream capacity increased and blood stream speed expedited. Meanwhile, the level of NO and ET were lowered markedly. There was significant difference between the two groups (P<0.05 or 0.01). Conclusion: The curative effect of Ruangan Granule was obvious on hepatocirrhosis with portal hypertension. The decreases of NO, ET may be one of the main mechanisms of Ruangan Granule regulating liver functions and decreasing the portal pressure.