上颌窦恶性肿瘤p21及nm23基因表达与复发转移的关系

Expressions of p21 and nm23:correlation with tumor metastasis and recurrence in maxillary sinus malignant tumor

目的探讨p21及nm23基因蛋白表达与上颌窦恶性肿瘤复发转移的关系。方法采用免疫组化S-P法对37例上颌窦恶性肿瘤组织的p21及nm23基因蛋白表达进行检测。所有患者均随访5年以上。结果上颌窦恶性肿瘤p21和nm23-H_1阳性表达均明显低于上颌窦良性肿瘤组织的表达,上颌窦恶性肿瘤中复发或转移组的p21及nm23-H_1阳性表达均明显低于无复发或转移者的表达,二者之间的差异有显著性。结论 p21基因与上颌窦恶性肿瘤浸润及复发转移有关,而nm23基因与复发转移有关。

To study the relationship between the expressions of nm23 and p21 with tumor metastasis and recurrence in maxillary sinus malignant tumors. Methods Using immunohistochemical S-P stainning, the expressions of nm23 and p21 were detected in 37 paraffin-embedded specimens of maxillary sinus malignant tumors. All patients were followed-up 5 years. Results The expressions of nm23 and p21 in maxillary sinus malignant tumors were lower than that of benign tumors, among them, the recurrence and/or metastasis maxillary sinus malignant tumors were lower than that of non-recurrence or metastasis maxillary sinus malignant tumors. But there was no difference between the expressions of nm23 in different T stage maxillary sinus malignant tumors. Conclusion Expression of p21 was closely correlated with the invasion and the recurrence and/or metastasis of maxillary sinus malignant tumors, while expressions of nm23 was just correlated with the invasion and the recurrence or metastasis of maxillary sinus malignant tumors.