单取代1,3-[2H,4H]-异喹啉二酮的合成

Synthesis of 4-Substituted 1,3-[2H,4H]-Isoquinolinedione

针对目前4-取代的1,3-[2H,4H]-异喹啉二酮合成方法较少的现状,从1,3-[2H,4H]-异喹啉二酮出发经过两步反应即可得到4-取代的1,3-[2H,4H]-异喹啉二酮,并以核磁共振氢谱(1HNMR),核磁共振碳谱(13CNMR)和高分辨质谱(HRMS)确定其化学结构。产物1,3-[2H,4H]-异喹啉二酮可以根据文献报道方法得到4-取代四氢异喹啉化合物,为4-取代的四氢异喹啉类化合物的合成提供了一条便捷的路径。

In view of the current situation that there are limited synthetic methods for the synthesis of 4-substituted 1,3-[2 H,4 H]-isoquinolinedione This article use the 1,3-[2 H,4 H]-isoquinolinedione as starting material and C-4 functionalized tetrahydroisoquinoline skeleton could be obtained in two steps,and the chemical structures are determined by proton nuclear magnetic resonance spectroscopy(1 HNMR),carbon nuclear magnetic resonance spectroscopy(13 CNMR)and high resolution mass spectrometer(HRMS).The product 1,3-[2 H,4 H]-isoquinolinedione can be transformed to tetrahydroisoquinoline compound using reported method,which provides a convenient route for the synthesis of tetrahydroisoquinoline compounds.