血清丙氨酸氨基肽酶和亮氨酸氨基肽酶的临床应用

Clinical Significance of Alanine Aminopeptidase and Leucine Aminopeptidase for Hepatobiliary Disease

目的 探讨血清丙氨酸氨基肽酶(AAP)和亮氨酸氨基肽酶(LAP)在肝胆疾病诊断中的应用价值。方法 采用速率法同时检测159例肝胆疾病患者血清AAP、LAP活性。结果 各种肝胆疾病患者血清AAP、LAP活性多有不同程度升高,升高幅度依次为:急性胆道疾病>原发性肝癌>急性黄疸性肝炎>肝硬化>转移性肝癌>慢性乙型肝炎,两者显著相关,相关系数r为0.976 2,P<0.01。与常见的三种肝酶ALT、ALP、GGT相比,AAP、LAP与ALP、GGT呈正相关,与ALT没有相关关系。结论 AAP和LAP在肝胆疾病诊断中的临床意义十分相似,为鉴别肝胆疾病类型提供了新的、有效的诊断依据。

Objective To compare clinical significance of alanine aminopeptidase(AAP) and leucme aminopeptidase(LAP) activity in serum for hepatobiliary disease. Methods Determining AAP and LAP activity in serum of 159 cases of hepato-biliary disease subjects in the meantime. Results AAP and LAP activity in serum were significantly higher for hepatobiliary disease subjects. Values increasing by degrees in order were acute disease of biliary trait .primary carcinoma of liver,a-cute icteric hepatitis, cirrhosis of liver,metastasis hepatocarcinoma and chromcity hepatitis B.It showed highly significant correlation between AAP and LAP in serum,correlation coefficient was 0. 976 2,.P<0. 01. Both of aminopeptidase were significant correlation with ALP and GGT. Conclusion Clinical value of AAP in serum is similar to LAP for hepatobiliary disease,both AAP and LAP are sensitive indicators of hepatobiliary disease.