摘要
应用阈值模型和可逆的跳跃马尔可夫链方法提出一种适用于人类一般家系中复杂二分类性状基因定位的连锁分析方法,此方法可以同时估计易感基因位点的数目与位置.
In this paper,a new method of linkage analysis is introduced which can be applied into general pedigrees to map genes affecting complex binary trait using threshold model and reversible jump Markov China Monte Carlo(MCMC) method.the number and locations of susceptibility genes can be estimated with this method simultaneously.
出处
《生物数学学报》
CSCD
2003年第1期15-20,共6页
Journal of Biomathematics
基金
国家自然科学基金资助项目(30170523)
