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血管内皮生长因子及受体在急性白血病中的表达及临床意义 被引量：1

Clinical significance of vascular endothelial growth factor and its receptors in acute leukemia
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摘要 目的 探讨血管生成在急性白血病(AL)发病、预后中的作用。方法 应用免疫组化法检测30例初治AL患者诱导化疗前后骨髓中微血管密度(MVD)、血管内皮生长因子(VEGF)及受体KDR、Flt-1变化与临床特征的关系。结果 初治AL患者骨髓组织中KDR、VEGF和MVD的表达高于对照组(P<0.05);完全缓解(CR)后MVD及VEGF阳性率明显下降;未完全缓解(NR)组的MVD及VEGF阳性率与治疗前无显著性下降(P>0.05);Kaplan-Meier分析显示治疗前VEGF阴性组的生存时间大于VEGF阳性组(P<0.05)。结论 AL骨髓中存在血管生成,VEGF与AL的发病及预后有关。
作者 张金巧 王金铠 李英敏
机构地区 河北医科大学附属第三医院血液科 河北医科大学附属第三医院病理学教研室
出处 《江苏医药》 CAS CSCD 北大核心 2003年第4期277-279,共3页 Jiangsu Medical Journal
关键词 临床意义 血管内皮生长因子 受体 急性白血病
分类号 R733.71 [医药卫生—肿瘤]
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参考文献7

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二级参考文献2

共引文献2

同被引文献17

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引证文献1

江苏医药
2003年 第4期

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