摘要
目的 :探讨HNPCC家族血清游离的氨基酸与矿物质的变化 ,为HNPCC家族的监测提供论据 ;方法 :用HPLC及原子吸收分光光度法检测正常人与HNPCC家族成员血清中游离氨基酸及Cu、Ca、Fe、Zn的含量 ;结果 :HNPCC组血清中Glu、Cys、Val高于正常对照组 ;而His、Pro、Leu、Phe低于正常对照组 ,血清Fe比正常人高 ,血清Ca低于正常人。结论 :血清中的部分游离氨基酸及Fe、Ca可作为HNPCC家族监测的间接指标。
In order to investigate the change of amino acids and minerals of HNPCC family serum and provide the clinic basis on the survey for HNPCC family members, twenty-five persons were divided into two groups(group HNPCC and group normal) and free amino acids were measured by HPLC and Cu?Ca?Fe?Zn were measured by atom absorption. The contents of Glu?Cys?Val?Fe in group HNPCC were higher than those in group normal and contents of His?Pro?Leu?Phe?Ca were lower than those in group normal(P<0.05). We can consider part of serum amino acids and Fe?Ca as indirect indexes for HNPCC family.
出处
《氨基酸和生物资源》
CAS
2003年第1期62-64,共3页
Amino Acids & Biotic Resources
