柳胺苄心定预防氯胺酮心血管反应的临床观察

The effect of labetalol on preventing cardiovascular reaction due to ketamine

目的 研究柳胺苄心定预防氯胺酮心血管反应的较佳剂量。方法 采用颈丛神经阻滞麻醉进行颈部手术的患者 90例 ,随机均分为 3组 ,因术中牵拉不适或麻醉不完全而予以静脉注射氯胺酮 0 .5mg/kg。A、B两组在静脉注射氯胺酮前 1min分别予静脉注射柳胺苄心定 0 .4mg/kg和 0 .2mg/kg ,C组不用柳胺苄心定。观察 3组患者用药前后的血压和心率变化。结果 A组用氯胺酮后患者的血压和心率最平稳 ,B、C两组的血压和心率均明显上升 ,以C组为甚。结论 在静脉注射氯胺酮 0 .5mg/kg前 ,静脉注射柳胺苄心定 0 .4mg/kg 。

Objective To study more ideal dosage of labetalol on preventing the cardiovascular reactions due to ketamine. Methods 90 patients were undertaken for cervical nerve block and injected ketamine 0.5 mg/kg intravenously for pain during the operation. They were divided into 3 groups. Group A and B were injected labetalol 0.4 mg/kg and 0.2 mg/kg intravenously before given ketamine but no administration for group C. The blood pressure and heart rate in all 3 groups were observed. Results The blood pressure and heart rate were stable in group A but increase in group B and C ( P <0.05) after injecting the ketamine. Conclusion Labetalol 0.4 mg/kg intravenously can prevent the cardiovascular reaction due to intravenous ketamine 0.5 mg/kg.