摘要
本文从胆色素肝肠循环基础理论入手,结合新生儿解剖生理特点以及微生态调节剂(MP)益生菌的生物特性进行综合分析,评述了新生儿胆红素肝肠循环特点以及MP干预新生儿黄疸的机制。阐明了新生儿胆色素肝肠循环以胆红素为主要内容,部分重吸收胆红素可经开放的静脉导管旁路入血。益生菌能降低肠道pH及氧化还原电势(Eh),抑制β-葡萄糖醛酸苷酶(β-GD)活性,促进胆红素最终变为粪、尿胆素,减少胆红素肝肠循环而减轻新生儿黄疸。
Based on the basic theories of enterohepatic bilirubin circulation, anatomical and physiological features of newborn are comprehensively analysed along with the biological properties of microecological preparation (MP) in this paper. The bilirubin enterohepatic circulation takes the bilirubin as the main substance, and part of the absorbed bilirubin may enter the systemic circulation through ductus venosus. The MP is probiotics able to decrease the pH of intestines and Eh, moreover, it accelerates the bilirubin and finally turns it into urobilin in the feces. MP can change the intestinal flora, suppresses the activaity of β-GD, secondly it accelerates bilirubin metabolism, which leads to decreasing the enterohepatic circulation. So it can be used to palliative newborn baby's jaundice.
出处
《儿科药学杂志》
CAS
2003年第2期8-10,共3页
Journal of Pediatric Pharmacy
关键词
胆红素
肝肠循环
微生态调节剂
干预
新生儿黄疸
Infant
Newborn
Bilirubin
Enterohepatic circulation
Microecological preparation
