RAb在自身免疫性甲状腺疾病中的临床价值

THE CLINICAL VALUE OF TRAb IN AUTOIMMUNE THYROID DISEASE

目的 :研究促甲状腺激素受体抗体 (TRAb)与自身免疫性甲状腺疾病 (AITD)的关系。方法 :采用放射受体法 (RRA)测定 185例AITD病人中TRAb的水平 ,与甲状腺激素进行相关性分析。结果 :与正常对照组相比 ,TRAb水平在Graves病 (GD)中存在显著性差异 (P <0 .0 1) ,且与FT3,FT4呈高度正相关 ,与sTSH呈高度负相关 ;在特发性粘液水肿中存在显著性差异 (P <0 ,0 1) ,且TRAb与FT4呈高度负相关 ,与sTSH呈高度正相关 ;在桥本氏甲状腺炎中无显著性差异 (P >0 .0 5 ) ,且TRAb与TGAb ,TMAb不相关。结论 :TRAb对AITD的诊断、鉴别诊断及疗效观察具有重要意义。

Objective:To study the relationship between serum TRAb and automumme thyroid disease(AITD).Methods:The levels of serum TRAb were measured in 185 patients of AITD by radioreceptorassay (RRA) and its correlation to thyroid hormone. Results: The levels of TRAb in Graves disease(GD) were significant higher than those of control group(P<0.01), which highly positive correlation to FT3,FT4 mid negative correlation to sTSH; so did the levels of TRAb in idiopathic myxedema but positive correlation to sTSH; the levels of TRAb in Hashimoto's thyroiditis had no significant difference as compared with that of control group (P>0.05), which highly no-correlated to TGAb, TMAb.Conclusion:TRAb plays an important role in diagnosis and treatment observation of AITD.