充血性心力衰竭患者血清细胞因子的变化及辛伐他汀的干预作用

TUMOR NECROSIS FACTOR-α AND INTERLEUKIN-6 IN CONGESTIVE HEART FAILURE AND THEIR CHANGES AFTER SIMVASTATIN TREATMENT

目的 :探讨充血性心力衰竭 (CHF)患者血清TNF -α和IL - 6的变化及辛伐他汀对其水平的影响。方法 :采用双抗体夹心ELISA法测定 44例CHF患者和 30例健康对照者血清TNT -α和IL - 6浓度 ;将CHF患者随机分为辛伐他汀组和常规治疗组治疗 ,15d后重复测定上述指标。结果 :CHF组患者血清TNT -α和IL - 6水平明显高于对照组 (P <0 .0 1) ,且与心功能损害程度密切相关 ;CHF组患者经 15d治疗后血清TNF-α和IL - 6水平均明显下降 (P <0 .0 5 ) ,但辛伐他汀组较常规治疗组血清TNT -α和IL - 6水平降低更为明显 (P <0 .0 5 )。结论 :CHF患者血清TNT -α和IL - 6水平明显增高且与心功能状态密切相关 ;在常规治疗的基础上加用辛伐他汀能进一步降低TNT -α和IL - 6的水平 ,提示辛伐他汀可能具有减缓心脏损伤的进程、保护和改善CHF患者心功能的作用。

Objective: To investigate the effects of simvastatin on cardiac function and serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6(IL-6) in patients with congestive heart failure(CHF). Methods: The levels of serum TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) in 44 CHF patients and 30 healthy subjects as controls. Patients with CHF were randomized to either conventional or conventional plus simvastatin groups. Cytokines were re-measured after 15 days.Results:The serum levels of TNF-α and IL-6 in patients with CHF were significantly higher than those of controls(P<0.01) and were related to their cardiac function status. The levels of TNF- α and IL-6 decreased during the treatment in both simvastatin group and conventional group, decreased levels of TNF-α and IL-6 were greater in simvastatin-treated group than in conventional group (P<0.05).Conclusion: Cardiac function status is correlated with levels of serum TNF-α and IL-6 in patients with CHF. Simvastatin may improve cardiac function by decreasing TNF-α and IL-6 in patients with CHF.