胰岛素泵治疗2型糖尿病临床研究

Clinical Study on Treating Type 2 Diabetes with Insulin-pump

目的 :研究短期胰岛素泵治疗初诊 2型糖尿病的临床疗效。方法 :1 2例初诊 2型糖尿病患者在饮食控制和运动治疗 4周血糖不能达到良好控制后 ,采用胰岛素泵持续皮下输注治疗 ( CSII) 2周 ,随后单纯控制饮食和运动治疗。结果 :CSII后 ,5例患者至本文撰稿时 ,先后达 3～ 1 3个月 ,平均6.6个月 ,单纯控制饮食和运动治疗 ,血糖控制满意。 4例须服二甲双胍 ,3例服磺脲类和双胍类药以控制血糖。CSII前后 ,1 2例 C肽、血脂及体重无明显变化。结论 :初诊 2型糖尿病及早开始短期的胰岛素泵强化治疗 ,部分患者在较长时间不用药物治疗情况下能达到良好糖代谢水平。但基础血糖较高 ,胰岛素抵抗或胰岛素分泌缺陷较严重患者仍须降糖药继续治疗。

Objective: To study the clinical curative effect of continuous subcutaneous infusion with insulin pump on newly diagnosed type 2 diabetes patients.Methods:12 cases of newly diagnosed type 2 diabetes were fixed with insulin pump and took continuous subcutaneous insulin infusion(CSII) for 2 weeks and following being treated with physical exercise and diet alone.Results: Before the time the article,5 patients were maintained on diet alone with adequate control from 3 to 13 months (median±SE,.6.6±3.78months),whose blood sugar getting better control.4 patients needed treating by mettormin,and 3 by sulfonylurea and mettormin. There were no significant difference in C peptide,lipidand weight before and after CSII. Conclusion:Some newly diagnosed type 2 diabets patients can get better sugar metabolism for a long period if they are treated early by continuous subcutaneous infusion with insulin pump.