乌拉地尔(利喜定)治疗颈椎前路手术中交感性心血管反应的临床观察

Clinical Observation of Urapidil in Treatment of Cardiovascular Response Induced by Sympathetic Stimu-lation During Front Approach Cervical Vertebra Operation

目的 :评价乌拉地尔治疗颈椎前路手术中交感性心血管反应的疗效。方法 :将120例颈椎前路手术患者随机均分为3组 ,在手术牵拉交感神经引起血压升高、心率加快时 ,乌拉地尔组和尼卡地平组分别给予乌拉地尔0 5mg/kg和尼卡地平5μg/kg,对照组则仅用异氟醚适当加深麻醉。结果 :乌拉地尔组患者给药后血压和心率均没有明显变化 ;尼卡地平组患者给药后血压虽无明显变化 ,但心率却显著加快 ;对照组虽经加深麻醉 ,但血压和心率都有明显的升高和加快。结论 :乌拉地尔能够有效治疗颈椎前路手术中患者交感性心血管反应。

OBJECTIVE:To evaluate the clinical effects of urapidil on cardiovascular response induced by sympathetic stimulation during front approach cervical vertebra operation.METHODS:One hundred and twenty patients undergoing front approach cervical vertebra operation were randomly divided into three groups.Patients in URA group treated with0.5mg/kg urapidil and patients in NIC group treated with5μg/kg nicardipine when systolic blood pressure(SBP)and heart rate(HR)increased by sympathetic nerve stimulation during the operation.And patients in COM group only increased their anesthesia degree with isoflurane at the same situation.The patients’SBP and HR were observed and compared among three groups at the time before the sympathetic nerve stimulation,and5minutes and10minutes after the drugs treatment respectiveˉly.RESULTS:The patients’SBP and HR in URA group had no significantly increase after administration of urapidil.In NIC group,although the patients’SBP had no significantly increase,the patients’HR increased significantly after nicardipine was used.But the patients’SBP and HR increased significantly after improved anesthesia degree with isoflurane.CONCLUSION:Urapidil has better effect on sympathetic cardiovascular response during the front approach cervical vertebra operation comˉpared with nicardipine.