室性心动过速的遗传学
摘要
由于分子生物学及功能性研究的不断进展，家族遗传性心律失常的病因已逐渐明晰，跨膜或细胞内离子通道的基因突变已经在遗传决定的多形性室速和猝死如儿茶酚胺源性室速、长QT综合征、Brugada综合征中被证实。由于不遵循孟德尔遗传法则，分子水平的异常在单形性室速发病中所起的作用目前尚未明确。但有趣的是，右室流出道单形性室速患者存在体细胞的基因突变，并被认为是此种室速的主要机制。今后利用分子遗传方法控制心律失常的目标是利用此项技术将患者的危险性进行更好地分层，并确定针对特发性室速特异靶基因的治疗。
出处
《世界医学杂志》
2003年第2期6-10,共5页
International Journal of Medicine
参考文献45
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