替米沙坦对原发性高血压和左心室肥厚的疗效

Effect of telmisartan on essential hypertension and left ventricular hypertrophy

目的 评价替米沙坦 (telmisartan)对轻、中度原发性高血压和左心室肥厚的疗效。 方法 198例高血压患者随机分为试验组和对照组。试验组 (n =99)服用替米沙坦 4 0～ 80mg/d ,对照组 (n =99)服用氯沙坦 5 0～ 10 0mg/d ,连服 2 4周。每周测血压一次。试验前、试验末各查 2 4h动态血压、心脏彩色多普勒超声。 结果 替米沙坦和氯沙坦均能有效降低血压 ,但替米沙坦在降低 2 4h平均舒张压方面优于氯沙坦(P <0 .0 1)。逆转左心室肥厚、改善左心室舒张功能两者无显著差异 (P >0 .0 5 )。 结论 替米沙坦对原发性高血压疗效确切 ,对左心室肥厚有逆转作用 。

Objective To evaluate the effect and safety of telmisartan on patients with mild and moderate essential hypertension and left ventricular hypertrohpy. Methods One hundred and ninety eight patients with mild and moderate essential hypertension were studied .The test group (n=99) were taken telmisartan (40～80mg/d) and the control group (n=99) were taken losartan (50～100mg/d)for 24 weeks. The blood pressure was measured once a week. The effect of drugs was assessed by dynamic blood pressure for 24 hours and color Doppler echocardiographic examinations at pre and post therapy.Results Telmisartan could reduce the blood pressure as well as losartan ,but the effect of telmisartan on controling mean DBP in 24 hours was better than losartan (P<0.01).Telmisartan could regress left ventricular hypertrophy and improve left ventricular diastolic function, but there was no significantly difference between two group(P>0.05) . Conclusion The effect of telmisartan on patients with essential hypertension is definite, and telmisartan can reverse left ventricular hypertrophy .