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P16基因在肾癌中的表达及其与生物学行为的关系 被引量：1

Expression of P16 protein in renal cell carcinoma
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摘要 目的 :研究P16基因在肾细胞癌中的表达及其与肾细胞癌生物学行为之间的关系。方法 :采用免疫组织化学方法检测肾细胞癌中P16基因表达情况。结果 :在肾细胞癌中 ,P16基因阳性表达率为 5 2 .9% ,在G1、G2 、G3 中 ,阳性表达率分别为 6 6 .7%、71.4 %和 37.0 % (P <0 .0 5 ) ,在透明细胞癌和颗粒细胞癌中 ,阳性表达率分别为 6 9.7%和 2 2 .2 % (P <0 .0 5 )。在阳性表达组和阴性表达组中 ,患者生存率差异有显著性意义。结论 :基因的表达与肾细胞癌的发生发展密切相关 。 Purpose:To study the correlation between P16 protein and tumorgrade,stage,prognosis of renal cell carcinoma(RCC).Methods:P16 protein was investigated in 51 cases of RCC using immunohistochemical technique.Results:The results showed that the total positive rate of P16 was 52.9 %. The P16 positive rate in gradeⅠ,Ⅱand Ⅲ was 66.7 %, 71.4 % and 37.0 %,respectively and was 69.7 % and 22.2 % in clear cell carcinoma and granular cell carcinoma.There was a significant difference in survival rate between P16 positive and negative cases.Conclusions:The result suggested that P16 play an important role in suppressing the development of renal cell carcinoma and can be used as a predictor of malignance and prognosis.
作者 王思齐 鲁功成
机构地区 温州医学院附属第一医院泌尿外科 华中科技大学同济医学院附属协和医院泌尿外科
出处 《临床泌尿外科杂志》 2003年第2期104-106,共3页 Journal of Clinical Urology
关键词 P16基因 肾癌 表达 生物学行为 病理 Kidney neoplasm Carcinoma P16 gene
分类号 R737.11 [医药卫生—肿瘤]
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参考文献9

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同被引文献15

  • 1僧靖静,赵高峰,卫利民,僧国珍,张云汉.胃癌组织中P16和Rb蛋白的表达[J].郑州大学学报（医学版）,2004,39(4):590-592. 被引量：6
  • 2高鹏,范晓琳,王培戈,陈咸增.p16和E-cadherin基因在胃癌中的表达[J].青岛大学医学院学报,2007,43(2):150-152. 被引量：6
  • 3Serrano M, Hannon GJ. Beech D. A new regulatory morf in cell cy-cle control causing specific inhibition of cyclinD/ CDK4[J]. Nature, 1993,399 : 704-707.
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  • 10Krecicki T, Smigel R, Fraczek M, et al. Studies of the cell cycle regulatory proteins P16,cyclin DI and retinoblastoma prtotein laryngeal carcinoma tissue[J]. J Laryngol Otol, 2004,118 : 676-680.

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临床泌尿外科杂志
2003年 第2期

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